SCCM Resource Library-Critical Care Immunotherapy

Video Transcription

Video Summary

In this video transcript, three different speakers discuss the topic of critical care immunotherapy. The first speaker, Steve Pastoris, introduces the session and the learning objectives, which include discussing the current applications of immunotherapy, describing the adverse events and toxicities associated with immunotherapy, and discussing the future of immunotherapy.<br /><br />The second speaker, Alfred Ayala, discusses the basic science behind immunotherapy as it relates to sepsis. He defines immunotherapy as a treatment that activates or suppresses the immune system to treat diseases such as arthritis, autoimmune disease, and cancer. He explains that in sepsis, immunotherapy is focused on balancing the immune response to infections and tissue injuries that lead to organ dysfunction and death. Ayala also discusses the role of antigen presentation, immune suppression, and immune-activating therapies in sepsis.<br /><br />The third speaker, Christina Gutierrez, focuses on the toxicities of immunotherapy and how they present in the ICU. She explains that immunotherapy, such as monoclonal antibodies, immune checkpoint inhibitors, and immune effector cells, can cause a range of toxicities affecting various organ systems. She emphasizes the importance of rapid diagnosis and close communication with oncologists when managing these toxicities. Gutierrez also highlights the potential of immunosuppressive therapies, such as corticosteroids and anti-cytokine therapy, in treating the toxicities.<br /><br />The video concludes with Richard Hotchkiss discussing the clinical implications of immunotherapy. He emphasizes the importance of targeting the host immune system in sepsis, particularly in patients with weakened immunity. Hotchkiss discusses the potential of immune-boosting therapies, such as interleukin-7 and checkpoint inhibitors, in improving host immunity and decreasing secondary infections. He also highlights the use of immunophenotyping, particularly the ELISPOT assay, to evaluate and track immune function in septic patients.<br /><br />Overall, the video provides an overview of critical care immunotherapy, including its potential applications, associated toxicities, and future implications for sepsis treatment.

Asset Subtitle

Immunology, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Discuss the current applications of immunotherapy
Discuss adverse events and toxicities associated with immunotherapy
Discuss the future of immunotherapy in critical illness

Biologic Basis of Immunotherapy
Alfred Ayala

Complications of Immunotherapy in the ICU
Cristina Gutierrez

Clinical Applications of Immunotherapy in the ICU
Richard Hotchkiss

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Level Advanced

Membership Level Select

Tag Autoimmune Diseases

Tag Oncology

Tag Infectious Diseases

Year 2021

Keywords

critical care immunotherapy

applications of immunotherapy

toxicities

sepsis

immune response

organ dysfunction

monoclonal antibodies

rapid diagnosis

immune-boosting therapies

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