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Critically Ill Children With Severe Sepsis Often H ...
Critically Ill Children With Severe Sepsis Often Have Sub-Target Meropenem Levels Early in Therapy
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Video Summary
Kelly Pace, a pediatric critical care fellow, discusses her research on meropenem target attainment in early severe sepsis in children. She explains that effective antibiotic therapy depends on maintaining concentrations above the minimum inhibitory concentration (MIC) for a certain period of time. However, due to the unique pharmacokinetics of severe sepsis, it is unclear how often pediatric patients achieve optimal antibiotic concentrations. Pace and her colleagues used opportunistic sampling, population-based PK modeling, and Bayesian estimation to assess meropenem target attainment in children with severe sepsis. They found that many patients did not consistently achieve sufficient meropenem concentrations, and lower clearance and higher illness severity were associated with increased target attainment. Further research is needed to optimize antibiotic dosing in this patient population.
Asset Subtitle
Pharmacology, Pediatrics, Sepsis, 2023
Asset Caption
Type: star research | Star Research Presentations: Pharmacology I (SessionID 30015)
Meta Tag
Content Type
Presentation
Knowledge Area
Pharmacology
Knowledge Area
Pediatrics
Knowledge Area
Sepsis
Membership Level
Professional
Membership Level
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Tag
Antibiotics
Tag
Sepsis
Tag
Pediatrics
Year
2023
Keywords
meropenem target attainment
severe sepsis in children
antibiotic therapy
pharmacokinetics
pediatric patients
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