SCCM Resource Library-Critically Ill Children With Severe Sepsis Often Have Sub-Target Meropenem Levels Early in Therapy

Critically Ill Children With Severe Sepsis Often Have Sub-Target Meropenem Levels Early in Therapy

Video Transcription

Video Summary

Kelly Pace, a pediatric critical care fellow, discusses her research on meropenem target attainment in early severe sepsis in children. She explains that effective antibiotic therapy depends on maintaining concentrations above the minimum inhibitory concentration (MIC) for a certain period of time. However, due to the unique pharmacokinetics of severe sepsis, it is unclear how often pediatric patients achieve optimal antibiotic concentrations. Pace and her colleagues used opportunistic sampling, population-based PK modeling, and Bayesian estimation to assess meropenem target attainment in children with severe sepsis. They found that many patients did not consistently achieve sufficient meropenem concentrations, and lower clearance and higher illness severity were associated with increased target attainment. Further research is needed to optimize antibiotic dosing in this patient population.

Asset Subtitle

Pharmacology, Pediatrics, Sepsis, 2023

Asset Caption

Type: star research | Star Research Presentations: Pharmacology I (SessionID 30015)

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area Pediatrics

Knowledge Area Sepsis

Membership Level Professional

Membership Level Select

Tag Antibiotics

Tag Sepsis

Tag Pediatrics

Year 2023

Keywords

meropenem target attainment

severe sepsis in children

antibiotic therapy

pharmacokinetics

pediatric patients

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