SCCM Resource Library-Development and Validation of the Phoenix Pediatric Sepsis Criteria

Video Transcription

All right. Thank you for coming, everyone. It's a little echoey. Hopefully, you guys are hearing us well. So on to the results.  So we were extremely proud and extremely excited to partner with 10 study sites around the world, six in higher resource settings and four in lower resource settings.  Here's a map of the distribution of our collaborators. You can see not only a wide distribution across the U.S., but also with partners in  Latin America, Africa, and Asia that were part of our database development. This was mostly EHR data and mostly between data comprising 2010 through 2019, although  some of the sites, for various reasons, when their databases were developed, provided less years.  The final cohort size for our development of our criteria was over 3.6 million pediatric hospital encounters.  We divided this dataset, this 3.6 million encounters, into two main datasets. On the left here in the slide, a little bit over 3 million patients were used for the  development of the criteria, of which about 170,000 had suspected infection in the first 24 hours. And then about 600,000 patients were retained for external validation.  These were patients in three different sites, two low-resource settings and one high-resource setting, for external validation of the criteria once the criteria were developed.  So those were held out until the end, and there were about 45,000 kids with suspected infection in the first 24 hours in that external validation set.  Of note here at the bottom, we excluded birth hospitalizations and children who had a postconceptual age of less than 37 weeks.  So this is not applicable to the premature babies, and hopefully that's future work that will continue and SCCM will hopefully sponsor.  Just because we're pediatricians and we like to compare ourselves to adults, this is the size of the task force datasets that the adult used on the red bar.  They used about 1.3 million encounters, most of them in the Pittsburgh, in the greater Pittsburgh area. And we used more than 3 million encounters from around the globe.  So this is, as of today, the largest database for the development of data-driven consensus definitions in medicine in general. So kudos to us in pediatrics.

Video Summary

The video transcript discusses a large-scale pediatric study involving over 3.6 million hospital encounters from 10 global study sites, including higher and lower resource settings across the U.S., Latin America, Africa, and Asia. The data from 2010 to 2019 mainly consisted of EHR data. Development criteria were based on nearly 3 million encounters, with 600,000 reserved for external validation across three sites. Premature infants were excluded from this study. The task force utilized more data than similar adult studies, making it the largest database for developing data-driven medical consensus definitions in pediatrics.

Asset Caption

Two-Hour Concurrent Session | Announcement of the Novel Phoenix Pediatric Sepsis Criteria

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

pediatric study

hospital encounters

global study sites

EHR data

medical consensus definitions

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