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Do Beta-Blockers Work? Clinical Trial Data
Do Beta-Blockers Work? Clinical Trial Data
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Video Summary
The speaker examines the potential use of beta blockers in critically ill patients, specifically in shock states, questioning if clinical data supports their application in such scenarios. Despite an inherent bias towards prescribing beta blockers due to their effectiveness in other conditions like acute coronary syndrome and heart failure, evidence in critically ill patients remains limited and varied. The trials available are small, often lack standardization regarding timing, patient selection, and outcome measures, such as mortality and dysrhythmia reduction. The recent STRESS-L trial testing Landolol in septic shock patients was halted due to adverse effects, suggesting early beta blocker use might be detrimental. The speaker stresses the need for careful patient selection, thorough evaluation of current conditions, and the gradual application of short-acting beta blockers in stable patients. Further trials need to focus on patient phenotyping, suitable hemodynamic targets, and optimal drug selection to establish beta blockers' efficacy in critically ill patients conclusively.
Asset Caption
One-Hour Concurrent Session | Flipping the Script: Beta-Blockers in Shock
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Content Type
Presentation
Membership Level
Professional
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Year
2024
Keywords
beta blockers
critically ill patients
shock states
STRESS-L trial
patient phenotyping
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