SCCM Resource Library-Dosing Medications in Liver Failure

Video Transcription

Video Summary

The speaker discusses how to dose medicines in patients with liver failure. They review the importance of liver metabolism in medication administration and discuss the challenges of using the child PUE score for dose adjustment. They explore alternative strategies for dose adjustment in liver failure and provide some recommendations. The speaker highlights the impact of liver failure on pharmacokinetics, including absorption, distribution, metabolism, and elimination. They explain how liver failure affects oral absorption and the first-pass effect. The speaker also discusses the impact of liver failure on distribution and metabolism. They emphasize the importance of considering factors such as drug characteristics, albumin levels, and hepatic blood flow. The speaker mentions the lack of evidence and guidelines for dose adjustment in liver failure and suggests a conservative approach to dosing. They also highlight specific medications with hepatic dose adjustments.

Asset Subtitle

Pharmacology, GI and Nutrition, 2023

Asset Caption

Type: two-hour concurrent | Liver Failure in the Pediatric ICU: Current Controversies (Pediatrics) (SessionID 1191837)

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area GI and Nutrition

Membership Level Professional

Membership Level Select

Tag Pharmacology

Tag Liver

Year 2023

Keywords

dose adjustment

liver failure

pharmacokinetics

oral absorption

distribution

metabolism

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