IV lorazepam is frequently on shortage due to increased demand and manufacturing delays, which may result in the need for alternative benzodiazepines (BZDs). IV lorazepam is commonly used in the ICU for seizures, sedation, anxiety, catatonia, intoxication, and substance withdrawal. In this alert, we will discuss commonly used BZDs (lorazepam, midazolam, diazepam) that may be used as alternatives to lorazepam. The recommendations provided in this document are based on both current evidence, including a review of available literature by the SCCM Drug Shortages and Medication Safety Committee, and the need for conservation during this shortage.