SCCM Resource Library-ESICM/SCCM Joint Session: Surviving Sepsis Campaign Research Priorities and Norepinephrine Challenges

ESICM/SCCM Joint Session: Surviving Sepsis Campaign Research Priorities and Norepinephrine Challenges

Video Transcription

Video Summary

Brittany Bissell Turpin, an advanced clinical pharmacist from Kentucky, presented on the challenges of norepinephrine concentration variability in critical care. Her task force, formed in late 2023, examined inconsistencies in reporting norepinephrine concentrations across different centers and countries. She highlighted that norepinephrine, like many drugs, is available in salt formulations necessary for intravenous administration due to low water solubility. Common formulations include norepinephrine bitartrate, tartrate, and hydrochloride, with the US favoring bitartrate and Europe using tartrate. These differences affect drug labeling and reporting, often leading to mismatches in reported concentrations between the salt and base formulations. This can result in significant implications for research, clinical guidelines, prognostication, and everyday clinical practice, potentially leading to incorrect dosing and treatment inconsistencies. Turpin advocated for a global standard of norepinephrine base reporting to enhance uniformity across institutions and countries. Task force co-chairs Ashish Khanna and Jan de Waal, along with other members, highlighted the importance of this standardization in ensuring consistent and safe patient care outcomes.

Asset Caption

One-Hour Concurrent Session | ESICM/SCCM Joint Session: Surviving Sepsis Campaign Research Priorities and Norepinephrine Challenges

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

norepinephrine

pharmacist

clinical care

concentration variability

drug formulations

standardization

patient safety

global reporting

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.