SCCM Resource Library-Epigenetic Mechanisms Determining Recovery of Immunostasis After Critical Insult

Video Transcription

Video Summary

Dr. Chris Haldanski presented his work on the epigenetic mechanisms that determine the recovery of the immune system after critical care insults at the 51st Critical Care Congress. He discussed the activation and deactivation of the immune system and how these processes are regulated. Dr. Haldanski focused on the abnormalities in epigenetic regulation that can affect the immune system's ability to recover favorably. He emphasized the importance of maintaining a balanced immune system response and the checkpoints necessary for regulation. Dr. Haldanski conducted experiments using patients who underwent cardiac surgery and found that three months after the surgery, some patients had an abundance of macrophages and a lack of dendritic cells. He attributed this to epigenetic changes in gene promoters, specifically the P1 promoter. Dr. Haldanski also conducted similar experiments in mice with sepsis and fruit flies with bacteremia, showing the conservative nature of epigenetic mechanisms. He concluded by emphasizing the importance of understanding and utilizing epigenetic regulation in treating patients in critical care.

Asset Subtitle

Immunology, 2022

Asset Caption

This session seeks to enlighten critical care practitioners on epigenetic mechanisms that determine recovery of immunostasis after acute critical illness. Speakers will highlight research developments on trained immunity as a new strategy to improve perioperative outcomes.

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Level Advanced

Membership Level Select

Tag Genetics

Year 2022

Keywords

epigenetic mechanisms

immune system recovery

critical care insults

abnormalities in regulation

balanced immune system response

gene promoters

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