SCCM Resource Library-Ethanol Represses LC3-Associated Phagocytosis via Sirtuin 2 in Human Macrophages

Ethanol Represses LC3-Associated Phagocytosis via Sirtuin 2 in Human Macrophages

Video Transcription

Video Summary

In this study, researchers investigated the role of a parameter called lactic base excess in septic patients. Lactic base excess is a measure of acid-base disturbances in the body and is used to assess kidney function in sepsis. The researchers hypothesized that a negative lactic base excess could indicate tubular dysfunction, even in patients with preserved glomerular function. They performed a retrospective cohort study including 1,178 septic patients. They found that negative lactic base excess was an independent predictor of in-hospital mortality, even in patients with preserved glomerular function. Patients with negative lactic base excess had higher mortality rates compared to patients with neutral lactic base excess. The study also found an association between lactic acidosis and acidemia in septic patients. These findings suggest that negative lactic base excess may be a marker of tubular dysfunction and could be used to predict outcomes in septic patients. Further research is needed to explore the potential use of lactic base excess in clinical practice.

Asset Subtitle

Research, 2023

Asset Caption

Type: star research | Star Research Presentations: Sepsis (SessionID 30011)

Meta Tag

Content Type Presentation

Knowledge Area Research

Membership Level Professional

Membership Level Select

Tag Research

Year 2023

Keywords

lactic base excess

septic patients

acid-base disturbances

kidney function

tubular dysfunction

in-hospital mortality

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