SCCM Resource Library-Evidence for or Against the Use of Inhalational Anesthetic Use Outside the OR

Evidence for or Against the Use of Inhalational Anesthetic Use Outside the OR

Video Transcription

Video Summary

The speaker discusses the use of inhalational volatile agents in ICU settings, highlighting the transition from operating rooms to intensive care, reasons for this shift, and their unique challenges and benefits. The focus is primarily on sevoflurane and isoflurane, which provide various advantages such as titratability, rapid on/off effects, reduced systemic metabolism, and minimal end-organ involvement, all contributing to potentially faster patient extubation. The discussion touches on comparisons with IV sedatives and the need to minimize sedative excess due to long recovery times and sedation-related side effects, such as neurocognitive dysfunction from prolonged benzodiazepine use. The speaker also highlights emerging data suggesting potential anti-inflammatory and organ-protective effects of inhalational agents, which could augment their use beyond sedation. Some trials, such as the CESAR and SAVE-ICU, are examining these agents' comprehensive efficacy and safety. Technical setup, environmental concerns, and challenges related to delivering these drugs in the ICU are also addressed, stressing the importance of staff training and the need for further research to confirm longer-term clinical outcomes and therapeutic benefits.

Asset Caption

45-Minute Session | FLUR-ishing: Inhalational Anesthetics in the ICU

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

inhalational volatile agents

ICU sedation

sevoflurane

isoflurane

anti-inflammatory effects

CESAR trial

SAVE-ICU trial

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