This article was first published in the Fall 2020 issue of Critical Connections.   It is a pattern that has been repeated in COVID-19 hot spots nationwide. Several weeks after the surge, emergency departments and intensive care units (ICUs) start seeing children, typically with fever and gastrointestinal issues. While almost all test positive for the SARS-CoV-2 virus or antibodies, they typically present after recovering from mild or asymptomatic COVID-19 with what appears to be a postinfectious response, now designated as multisystem inflammatory syndrome in children (MIS-C).   Critical Connections is the critical care industry’s only newsmagazine, provides information on cutting-edge topics in critical care useful to the entire multiprofessional team.