SCCM Resource Library-Future Direction: Trained Immunity to Impact Outcomes in Perioperative and Critical Care Medicine

Future Direction: Trained Immunity to Impact Outcomes in Perioperative and Critical Care Medicine

Video Transcription

Video Summary

In this video, Tony Hernandez discusses the concept of trained immunity and its potential impact on perioperative and critical care medicine. He begins by highlighting the rising threat of microbial resistance, with many antibiotics becoming ineffective within a few years of their development. Traditional strategies of relying on pharmaceutical companies to develop new drugs are no longer viable, and Washington has introduced incentives to combat antibiotic resistance. Hernandez then explains that trained immunity involves the induction of innate immune memory against pathogens. Toll-like receptor 4 agonists, such as MPLA, can activate innate immune cells and induce trained immunity. Animal studies have shown that MPLA treatment improves survival and reduces bacterial burden in infection models. Furthermore, trained immunity has shown promise in protecting against ischemia-reperfusion injury and preserving organ function. Hernandez concludes by highlighting the potential of phosphorylated hexaacyl disaccharides as candidates for pharmaceutical development.

Asset Subtitle

Immunology, 2022

Asset Caption

This session seeks to enlighten critical care practitioners on epigenetic mechanisms determining recovery of immunostasis after acute critical illness. Besides, it highlights research developments of trained immunity as a new strategy to improve perioperative outcomes.

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Level Advanced

Membership Level Select

Tag Genetics

Year 2022

Keywords

trained immunity

perioperative care

critical care medicine

microbial resistance

innate immune memory

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