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GJA1-20k Reduces Resuscitation Requirements and Re ...
GJA1-20k Reduces Resuscitation Requirements and Renal Injury Post-REBOA Ischemia-Reperfusion Injury
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Video Summary
REBOA (Resuscitative Endovascular Balloon Occlusion of the Aorta) is a life-saving tool used to treat non-compressible torso hemorrhages. However, it comes with the risk of ischemia reperfusion injury. This study focused on the use of GGA120K, which stabilizes mitochondria and mitigates oxidative stress. The study involved Yorkshire pigs subjected to hemorrhagic shock and treated with REBOA. The results showed that the animals treated with GGA120K required significantly less fluid for resuscitation compared to the control group. GGA120K also reduced renal injury and showed immunomodulation effects. The study suggests that GGA120K could be used in combination with other mitochondrial pharmaceuticals for improved outcomes in REBOA treatment.
Asset Subtitle
Renal, Resuscitation, Trauma, 2023
Asset Caption
Type: star research | Star Research Presentations: Pharmacology II (SessionID 30016)
Meta Tag
Content Type
Presentation
Knowledge Area
Renal
Knowledge Area
Resuscitation
Knowledge Area
Trauma
Membership Level
Professional
Membership Level
Select
Tag
Renal
Tag
Fluids Resuscitation Management
Year
2023
Keywords
REBOA
non-compressible torso hemorrhages
GGA120K
renal injury
immunomodulation
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