SCCM Resource Library-Hitting More Than the Target: Toxicities of Immune Checkpoint Inhibitors and Other Targeted Therapies for Cancer

Hitting More Than the Target: Toxicities of Immune Checkpoint Inhibitors and Other Targeted Therapies for Cancer

Video Transcription

Video Summary

The presentation focused on the toxicities associated with immune checkpoint inhibitors, immune effector cell therapy, monoclonal antibodies, and CAR T-cell therapies in cancer treatment. These therapies revolutionize cancer care by enhancing immune responses against cancer cells but can cause severe side effects like cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). CRS is a hyperinflammatory response common in CAR T-cell therapy, potentially landing patients in ICU due to severe symptoms. ICANS, another side effect, can vary from mild symptoms to life-threatening conditions like cerebral edema. Management involves steroids and tocilizumab, targeting cytokine pathways. Monoclonal antibodies can cause hypersensitivity and organ-specific toxicities. Immune checkpoint inhibitors, effective in solid organ malignancies, can induce a range of immune-related adverse effects affecting multiple body systems. Early recognition and collaboration with oncologists are crucial for managing these toxicities while minimizing disruptions to lifesaving cancer treatments.

Asset Caption

One-Hour Concurrent Session | New Drug, Who's Toxic? New and Emerging Drug Toxicities

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

immune checkpoint inhibitors

CAR T-cell therapy

cytokine release syndrome

immune effector cell-associated neurotoxicity

monoclonal antibodies

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