SCCM Resource Library-How Can We Apply Animal and Human Studies to Children?

Video Transcription

Video Summary

In this video, the speaker discusses the application of animal and human studies to understand COVID-19 in children. They start by noting that children have better outcomes compared to adults, although it's unclear if they are less infectious or if they have equal infectivity but less severe symptoms. The speaker explains that children may have pre-existing and de novo humoral immunity to SARS-CoV-2, which is partly due to cross-reacting coronavirus antibodies found in their system. They also mention a mouse model that suggests age-related differences in immune function contribute to children's resistance to COVID-19. In terms of vaccination, young mice generate a better antibody response. Children not only have a milder phenotype for the same viral load, but their innate immune response also resolves faster than adults without sacrificing immune function. The speaker discusses how the immune response differs between adults and children and how these differences may contribute to the milder disease course in children. They also focus on the immunopathological signature of MIS-C, which shows an exaggerated T cell response and potential targeting of the endothelium. However, it is important to note that MIS-C data is limited by small sample size and concurrent immunomodulation treatment.

Asset Subtitle

Immunology, Pediatrics, Infection, 2022

Asset Caption

This session will examine and explain the progress made in the understanding of the immunology of sepsis following the COVID-19 pandemic. Speakers will bring fresh insights from large international cohorts and detailed molecular mechanistic studies.

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Area Pediatrics

Knowledge Area Infection

Knowledge Level Advanced

Membership Level Select

Tag Pediatrics

Tag COVID-19

Tag Infectious Diseases

Year 2022

Keywords

COVID-19 in children

animal studies

human studies

immunity to SARS-CoV-2

age-related differences in immune function

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