How Slow Can You Go? Alternate Dosing Strategies for Beta-Lactam Antibiotics
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Video Transcription
Video Summary
Asset Subtitle
Pharmacology, 2022
Asset Caption
Guidelines for vancomycin area under the curve (AUC)/minimum inhibitory concentration (MIC) monitoring were published by the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists in March 2020. Many institutions are developing new protocols for monitoring vancomycin, including the updated recommendation from the guidelines to use AUC/MIC monitoring in place of traditional trough monitoring. In addition, recent literature has promoted the use of continuous infusion beta-lactam dosing. In this flipped classroom session, attendees will bring local protocols and dosing schemes to launch a comparison with the newly published guidance and compare strategies by using audience polling. This session will also review the advantages and disadvantages of 2 level AUC pharmacokinetics and more advanced Bayesian AUC pharmacokinetics in an interactive session using simulated patient data, including initial dosing schemes and dosage revisions. A similar approach will be taken to determine time > MIC dosing for beta-lactam antibiotics using therapeutic drug monitoring techniques and extended/continuous infusion dosing approaches.
Meta Tag
Content Type Presentation
Knowledge Area Pharmacology
Knowledge Level Intermediate
Knowledge Level Advanced
Membership Level Select
Tag Antibiotics
Tag Pharmacokinetics Pharmacodynamics
Year 2022
antibiotic dosing
critically ill patients
beta-lactam antibiotics
aggressive dosing
prolonged infusions
therapeutic drug monitoring
pharmacokinetic target attainment


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