SCCM Resource Library-Identification of Molecular Endotypes in Two Cohorts of Pediatric ARDS

Identification of Molecular Endotypes in Two Cohorts of Pediatric ARDS

Video Transcription

Video Summary

The transcript discusses the identification of molecular subtypes in pediatric acute respiratory distress syndrome (ARDS) using biomarkers. The study analyzed two cohorts of children with ARDS and identified hyper-inflammatory and hypo-inflammatory subtypes based on levels of specific biomarkers. The hyper-inflammatory subtype showed worse outcomes and elevated biomarkers associated with innate immunity and endotheliopathy. Additionally, the study found a potential differential response to steroid treatment based on the subtype, with steroids appearing to be protective in the hypo-inflammatory subtype and potentially harmful in the hyper-inflammatory subtype. The findings suggest the potential for prognostic enrichment and personalized treatment approaches in pediatric ARDS.

Asset Subtitle

Pediatrics, Pulmonary, 2023

Asset Caption

Type: star research | Star Research Presentations: Biomarkers I, Pediatrics (SessionID 30007)

Meta Tag

Content Type Presentation

Knowledge Area Pediatrics

Knowledge Area Pulmonary

Membership Level Professional

Membership Level Select

Tag Acute Respiratory Distress Syndrome ARDS

Tag Pediatrics

Year 2023

Keywords

molecular subtypes

pediatric acute respiratory distress syndrome

biomarkers

hyper-inflammatory subtype

hypo-inflammatory subtype

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