SCCM Resource Library-Immune Response Transition During Sepsis Progression

Immune Response Transition During Sepsis Progression

Video Transcription

Video Summary

The presentation focused on understanding and transitioning immune responses in sepsis, from hyperinflammation to persistent inflammation and immunosuppression. Historical insights into sepsis treatment and research were discussed, emphasizing the failure of early interventions. A mouse model experiment demonstrated how immune responses change over time in sepsis, highlighting terms like hyperinflammation and hypoinflammation. The speaker introduced the role of epigenetics, specifically sirtuins, in regulating these immune responses, suggesting potential therapeutic targets. The goal of future treatments should be phase-specific, aiming to restore immune homeostasis. The talk ended with acknowledgments and an invitation for questions.

Asset Caption

One-Hour Concurrent Session | Changing Face of Immune Response in Sepsis

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

sepsis

immune responses

epigenetics

sirtuins

therapeutic targets

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