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Immunologic Markers of Sepsis
Immunologic Markers of Sepsis
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Video Summary
The presentation discusses advancements in precision medicine, particularly in relation to sepsis treatment. It underscores the shift from traditional evidence-based medicine, which bases treatments on the average population, to precision medicine that considers individual genetic and environmental factors in treatment plans. Highlighting sepsis's complexity, the presentation explains the failure of past immunotherapies due to heterogeneous disease presentations and inadequate trial designs. It examines the roles of biomarkers and phenotypes in identifying patient-specific responses but highlights current limitations, such as insufficient predictive biomarkers for sepsis. It contrasts phenotypes, observable clinical characteristics, with endotypes, the underlying biological mechanisms, stressing the importance of endotypes in accurately targeting mechanistic therapies. The presentation outlines future directions, including rapid diagnostic technologies and advanced genomic tools to enable personalized treatment strategies, emphasizing the potential for enhanced clinical trials and the realization of precision medicine.
Asset Caption
One-Hour Concurrent Session | Changing Face of Immune Response in Sepsis
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Content Type
Presentation
Membership Level
Professional
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Year
2024
Keywords
precision medicine
sepsis treatment
biomarkers
phenotypes
endotypes
genomic tools
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English