SCCM Resource Library-Immunologic Markers of Sepsis

Video Transcription

Video Summary

The presentation discusses advancements in precision medicine, particularly in relation to sepsis treatment. It underscores the shift from traditional evidence-based medicine, which bases treatments on the average population, to precision medicine that considers individual genetic and environmental factors in treatment plans. Highlighting sepsis's complexity, the presentation explains the failure of past immunotherapies due to heterogeneous disease presentations and inadequate trial designs. It examines the roles of biomarkers and phenotypes in identifying patient-specific responses but highlights current limitations, such as insufficient predictive biomarkers for sepsis. It contrasts phenotypes, observable clinical characteristics, with endotypes, the underlying biological mechanisms, stressing the importance of endotypes in accurately targeting mechanistic therapies. The presentation outlines future directions, including rapid diagnostic technologies and advanced genomic tools to enable personalized treatment strategies, emphasizing the potential for enhanced clinical trials and the realization of precision medicine.

Asset Caption

One-Hour Concurrent Session | Changing Face of Immune Response in Sepsis

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

precision medicine

sepsis treatment

biomarkers

phenotypes

endotypes

genomic tools

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