SCCM Resource Library-Immunomodulation in Kids: More Than Growing Up?

Video Transcription

Video Summary

In this video, the speaker discusses the cytokine storm and its impact on critically ill children. They explain that while hyperinflammation is commonly observed in the ICU, there is also an underappreciated immune suppression occurring at the same time. To study this, they use the ex vivo LPS induced TNF alpha production capacity assay, which measures the production of inflammatory cytokines in response to stimulation. They find that children with multiple organ dysfunction syndrome and sepsis have lower production capacity compared to healthy children. The speaker also highlights the need for personalized immunomodulation strategies to restore immune balance and improve outcomes for these patients.

Asset Subtitle

Immunology, Pediatrics, 2023

Asset Caption

Type: two-hour concurrent | Immunomodulation in Critical Illness: A 2023 Update (SessionID 1161720)

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Area Pediatrics

Membership Level Professional

Membership Level Select

Tag Immunology

Tag Pediatrics

Year 2023

Keywords

cytokine storm

critically ill children

immune suppression

ex vivo LPS induced TNF alpha production capacity assay

personalized immunomodulation strategies

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