SCCM Resource Library-Immunomodulation in Perioperative Care

Video Transcription

Video Summary

In this video, the speaker discusses the rising threat of microbial resistance and the need for new approaches to combat antibiotic resistance. They introduce the concept of trained immunity, which involves inducing innate immune memory against pathogens. They discuss the use of Toll-like Receptor 4 (TLR4) agonists to induce trained immunity and present two models they have developed and tested using these agonists. The first model focuses on pneumonia, while the second model examines ischemia-reperfusion-induced acute kidney injury. The speaker concludes by emphasizing the potential of trained immunity to enhance antimicrobial functions and preserve organ function, particularly in perioperative medicine.

Asset Subtitle

Immunology, 2023

Asset Caption

Type: two-hour concurrent | Immunomodulation in Critical Illness: A 2023 Update (SessionID 1161720)

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Membership Level Professional

Membership Level Select

Tag Immunology

Year 2023

Keywords

microbial resistance

trained immunity

TLR4 agonists

pneumonia

acute kidney injury

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