SCCM Resource Library-Immunomodulator Management for COVID-19

Video Transcription

Video Summary

In this video, Alexandra Barber, a medical ICU clinical pharmacy specialist, discusses the management of immunomodulators for the treatment of COVID-19. She reviews the immune response kinetics of SARS-CoV-2 and identifies opportunities to target the inflammatory response in COVID-19 patients. Barber focuses on three immunomodulators: steroids, tocilizumab, and baricitinib. She discusses key trials for each medication and their efficacy in reducing mortality and improving patient outcomes. Barber recommends using dexamethasone as an initial treatment for patients with an increased oxygen requirement. She suggests considering tocilizumab or baricitinib as adjunct therapies to dexamethasone in patients with severe symptoms and ongoing inflammation. Barber emphasizes the importance of timing the administration of these medications and highlights the need for more data and head-to-head trials to determine the optimal management strategies for COVID-19.

Asset Subtitle

Immunology, Infection, 2022

Asset Caption

This session will cover the current understanding of COVID-19-related immune response, including moderate and severe disease, plus immune response to vaccination.

Meta Tag

Content Type Presentation

Knowledge Area Immunology

Knowledge Area Infection

Knowledge Level Advanced

Membership Level Select

Tag Infectious Diseases

Tag COVID-19

Year 2022

Keywords

immunomodulators

COVID-19

steroids

tocilizumab

baricitinib

patient outcomes

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