SCCM Resource Library-Incidence of Detectable Drug Levels With Inhaled Aminoglycoside Therapy in Critically Ill Adults

Incidence of Detectable Drug Levels With Inhaled Aminoglycoside Therapy in Critically Ill Adults

Video Transcription

Video Summary

The speaker discusses their research project on the use of inhaled aminoglycosides in critically ill adults. Inhaled aminoglycosides are commonly used for pulmonary infection treatment and prevention due to their high concentration in the lungs. However, there is limited understanding of their systemic accumulation. The study analyzed drug levels in 93 patients in the intensive care unit who received inhaled amikacin or tobramycin. They found that 41.9% of the drug levels were detectable, with a median detectable drug level of 0.9 micrograms per mil for tobramycin and 3.7 for amikacin. Therapy modifications were made for the majority of patients with detectable drug levels. The speaker suggests that periodic trough concentration monitoring should be considered for critically ill patients receiving inhaled aminoglycosides. Further research is needed to explore dose adjustments and evaluate clinical efficacy and safety outcomes.

Asset Subtitle

Pharmacology, 2023

Asset Caption

Type: star research | Star Research Presentations: Pharmacology I (SessionID 30015)

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Membership Level Professional

Membership Level Select

Tag Antibiotics

Year 2023

Keywords

inhaled aminoglycosides

critically ill adults

pulmonary infection treatment

systemic accumulation

drug levels

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