SCCM Resource Library-Internal Medicine Review 1

Video Transcription

Video Summary

In this presentation, the speaker discusses the latest research on therapies for COVID-19 critical illness. They focus on three treatments: steroids, anti-interleukin-6 therapies, and Janus kinase (JAK) inhibitors. The speaker explains that in the early stages of COVID-19, antivirals are commonly used to inhibit viral replication. However, as patients progress into moderate and severe illness, inflammation becomes a major driver of organ injury. Steroids, such as dexamethasone, have shown significant benefits in reducing mortality in severe COVID-19 cases. Anti-interleukin-6 therapies, like tocilizumab and sarilumab, have been shown to be effective in reducing mortality and organ support days in critically ill patients. The JAK inhibitor, baricitinib, has also demonstrated potential benefits in reducing mortality. The speaker also highlights other important research areas, such as COVID-19 epidemiology, the impact of air pollution exposure, anticoagulation, and the multisystem inflammatory syndrome.

Asset Subtitle

Research, Quality and Patient Safety, 2022

Asset Caption

This session will highlight the latest research, lessons learned, and changes taking place in critical care internal medicine practice during the past year.

Meta Tag

Content Type Presentation

Knowledge Area Research

Knowledge Area Quality and Patient Safety

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Outcomes Research

Tag Evidence Based Medicine

Year 2022

Keywords

COVID-19 critical illness

steroids

anti-interleukin-6 therapies

Janus kinase inhibitors

mortality

organ support days

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