SCCM Resource Library-Invasive Candidiasis

Video Transcription

Video Summary

Invasive candidiasis is a common and serious infection in ICU patients. The speaker discussed guidelines published in 2019 and 2021 regarding the diagnosis and treatment of invasive candidiasis in non-neutropenic ICU patients. The first guideline recommended echinocandins as the first treatment option for critically ill patients with septic shock and multi-organ failure. The second guideline assigned the highest recommendation to echinocandins as the agent of choice for ICU treatment. The speaker also discussed the use of beta-D-glucan as a diagnostic biomarker for invasive candidiasis. While it can serve as a red flag for the possibility of a fungal infection, it is not sufficient for diagnostic decision-making due to its low sensitivity. Prophylactic antifungal therapy was not recommended for routine use in critically ill patients, and there is no evidence to support the use of preemptive antifungal therapy. Empirical antifungal therapy may be considered in patients with septic shock and multi-organ failure who have multiple sites of candida colonization. However, there is no evidence of a mortality benefit from empirical therapy.

Asset Subtitle

Infection, 2023

Asset Caption

Type: two-hour concurrent | Updates on Infectious Disease Guidelines in Critical Care (SessionID 1229708)

Meta Tag

Content Type Presentation

Knowledge Area Infection

Membership Level Professional

Membership Level Select

Tag Fungal Infections

Year 2023

Keywords

invasive candidiasis

ICU patients

echinocandins

beta-D-glucan

empirical antifungal therapy

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