SCCM Resource Library-Is COVID-19 a Cytokine Storm or Immune Exhaustion?

Video Transcription

Video Summary

In this video, Dr. Kenneth Remy from Case Western University discusses the controversial topic of COVID-19 and its impact on the immune system. He explains that COVID-19, caused by the SARS-CoV-2 virus, can lead to both a cytokine storm and immune exhaustion. The cytokine storm is an overactivation of the immune response, characterized by elevated levels of cytokines, which can result in systemic inflammation and organ dysfunction. On the other hand, immune exhaustion is a state of T cell dysfunction that arises in chronic infections, including COVID-19, characterized by poor effector function and sustained expression of inhibitory receptors. Dr. Remy and his team conducted studies comparing COVID-19 patients to septic patients and found similarities in immune dysregulation and suppression. They also observed differences in cytokine levels and T cell exhaustion between the two groups. The findings suggest that COVID-19 may have both hyperinflammatory and immune suppressive phases, and that therapeutic strategies should be tailored accordingly.

Asset Subtitle

Sepsis, Infection, 2022

Asset Caption

This session will review traditional and new biomarkers in the setting of COVID-19, sepsis, and post-cardiac arrest.

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Infection

Knowledge Level Intermediate

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Tag Cytokine

Tag COVID-19

Year 2022

Keywords

COVID-19

immune system

cytokine storm

immune exhaustion

SARS-CoV-2 virus

T cell dysfunction

Sepsis

Infection

Cytokine

Presentation

Select

2022

Intermediate

Advanced

Sepsis Resources

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