SCCM Resource Library-Is Renin the New Lactate for Tissue Perfusion and Prognosis?

Video Transcription

Video Summary

In this video, Ashish Khanna discusses the use of renin in critically ill patients for tissue perfusion and prognosis. He explains that the renin-angiotensin system, along with the sympathetic nervous system and arginine vasopressin, is involved in regulating blood pressure in these patients. He discusses studies that have shown the effectiveness of angiotensin II in treating shock and improving hemodynamic stability. Khanna also explains how ACE, the enzyme that converts angiotensin I to angiotensin II, is impaired in conditions like acute lung injury, leading to a disruption in the renin-angiotensin system. He discusses the non-classical pathway of angiotensin metabolism and the role of renin in predicting tissue perfusion and mortality in critically ill patients, suggesting that renin may be a better marker than lactate. Khanna also presents data showing the benefits of angiotensin II treatment and the association between renin levels and mortality. He concludes by mentioning the need for strategies to reduce the use of catecholamines in critically ill patients and highlights ongoing research in this area.

Asset Subtitle

Sepsis, Infection, 2022

Asset Caption

This session will review traditional and new biomarkers in the setting of COVID-19, sepsis, and post-cardiac arrest.

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Infection

Knowledge Level Intermediate

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Tag Sepsis

Tag COVID-19

Year 2022

Keywords

renin

critically ill patients

tissue perfusion

mortality prediction

angiotensin II treatment benefits

Sepsis

Infection

Sepsis

Presentation

Select

2022

COVID-19

Intermediate

Advanced

Sepsis Resources

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