SCCM Resource Library-January Journal Club Webcast: Spotlight on Pharmacy (2022)

Video Transcription

Video Summary

In this Journal Club Spotlight on Pharmacy webcast, three presenters discussed different topics related to critical care pharmacy. The first presenter, Kaitlin Fellers, discussed the impact of opioid administration in the intensive care unit (ICU) and subsequent use in opioid-naive patients. She highlighted the opioid epidemic and the need to evaluate opioid utilization in the ICU. Kaitlin reviewed a study that examined the relationship between ICU opioid administration and opioid prescriptions at discharge. The study found no significant relationship between ICU opioid dose and opioid prescriptions at discharge. However, longer non-ICU length of stay and certain admission diagnoses were associated with opioid prescriptions at discharge. Kaitlin suggested re-examining IV push versus enteral opioids and developing a standardized process for opioid weaning in the ICU. The second presenter, Alyssa Megan, discussed the use of midodrine as a vasopressor weaning modality in ICU patients on low-dose vasopressor infusions. Alyssa reviewed previous studies that examined the safety and efficacy of midodrine in this patient population. She presented the results of the trial which compared midodrine plus vasopressors versus vasopressors alone. The trial found that midodrine was not superior or non-inferior to standard care in terms of vasopressor cessation or clinical outcomes. Alyssa concluded by suggesting individualizing the use of midodrine based on patient characteristics and further research in alternative patient populations. Lastly, Jill Davenport presented on a trial that examined the use of intravenous alteplase before endovascular treatment for stroke. She highlighted previous studies that showed conflicting results regarding the use of alteplase in combination with endovascular treatment. The trial evaluated the efficacy of endovascular treatment alone versus alteplase followed by endovascular treatment. The trial did not find a significant difference in functional outcomes between the two groups. Jill concluded that more studies are needed to determine the role of alteplase in addition to endovascular treatment in this patient population. Overall, the webcast provided insights into the impact of opioids in the ICU, the use of midodrine in vasopressor weaning, and the efficacy of alteplase in stroke treatment.

Asset Subtitle

Pharmacology, 2022

Asset Caption

"The Journal Club: Spotlight on Pharmacy webcast series focuses on pharmacy topics. This event is held on the third Friday of each month and features lively discussion and in-depth presentations on the latest research.

Follow the conversation at #SCCMCPPJC."

Meta Tag

Content Type Webcast

Knowledge Area Pharmacology

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Tag Analgesia and Sedation

Year 2022

Keywords

critical care pharmacy

opioid administration

ICU opioid dose

opioid prescriptions

midodrine

vasopressor weaning

clinical outcomes

alternative patient populations

stroke treatment

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