SCCM Resource Library-July Journal Club Webcast: Spotlight on Pharmacy (2022)

Video Transcription

Video Summary

In today's Journal Club Spotlight on Pharmacy webcast, three presenters discussed different topics related to critical care pharmacy. The first presenter, Dr. Heather Wilson, discussed a randomized control trial on the use of vitamin C monotherapy in septic shock. She highlighted previous studies on vitamin C therapy and discussed the results of the trial, which found that continuous infusion of vitamin C did not reduce mortality in septic shock patients. The second presenter, Dr. Sam Markle, discussed a comparison of thrombolytic agents, tenecteplase and alteplase, for the treatment of ischemic stroke. He discussed the potential benefits of tenecteplase over alteplase and presented the results of a study conducted in a mobile stroke unit. The study found that tenecteplase was associated with a faster time to thrombolysis and reduced perfusion lesion volume. The third presenter, Dr. Aaron Ipho, discussed a retrospective cohort study on the timing of antibiotics in septic shock patients. The study found that delaying antibiotic administration increased the risk of progression to septic shock, with the highest risk occurring within the first five hours of delay. The presenters concluded that vitamin C monotherapy is not recommended for septic shock, tenecteplase may be a reasonable alternative to alteplase for ischemic stroke, and early antibiotic administration is important to prevent progression to septic shock.

Asset Subtitle

Pharmacology, Sepsis, Neuroscience, 2022

Asset Caption

"The Journal Club: Spotlight on Pharmacy webcast series focuses on pharmacy topics. This event is held on the third Friday of each month and features lively discussion and in-depth presentations on the latest research.

Heather Wilson, PharmD
Wacker DA, Burton SL, Berger JP, et al. Evaluating vitamin C in septic shock: a randomized controlled trial of vitamin C monotherapy. Crit Care Med. 2022 May;50(5):e458-e467.

Sam Markle, PharmD
Bivard A, Zhao H, Churilov L, et al. Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne mobile stroke unit (TASTE-A): a phase 2, randomised, open-label trial. Lancet Neurol. 2022 Jun;21(6):520-527.

Aaron Effoe, PharmD
Bisarya R, Song X, Salle J, Liu M, Patel A, Simpson SQ. Antibiotic timing and progression to septic shock among patients in the ED with suspected infection. Chest. 2022 Jan;161(1):112-120.

Follow the conversation at #SCCMCPPJC."

Meta Tag

Content Type Webcast

Knowledge Area Pharmacology

Knowledge Area Sepsis

Knowledge Area Neuroscience

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Tag Pharmacology

Tag Cerebral Ischemia

Tag Shock

Year 2022

Keywords

critical care pharmacy

vitamin C monotherapy

septic shock

thrombolytic agents

tenecteplase

alteplase

ischemic stroke

mobile stroke unit

timing of antibiotics

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