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Keeping Up the Pressure: Steroid Management
Keeping Up the Pressure: Steroid Management
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Video Transcription
Video Summary
In this video transcript, the speaker discusses the use of hydrocortisone in therapy and its effects on blood pressure. In both septic adult and pediatric patients, hydrocortisone has been shown to raise blood pressure. The mechanism of this increase is not completely clear, but it is believed to involve a reduction in nitric oxide production. The speaker also explains the differences between the anterior and posterior pituitary gland and their communication with the brain. In the context of brain death, there is an initial phase called autonomic storm, which is similar to pituitary apoplexy. This phase is followed by a phase of necrosis and apoptosis where hormone production decreases. The speaker then compares the effects of glucocorticoids in sepsis and organ donation, highlighting their hemodynamic and immune effects. The use of hydrocortisone has been shown to enhance organ recovery in adult studies, leading to recommendations for its use in pediatric brain death cases. However, there are still unanswered questions regarding dosing, titration, and duration of therapy.
Asset Subtitle
Pharmacology, 2023
Asset Caption
Type: one-hour concurrent | The Endocrine System Must Live on in Severe CNS Illness and Injury (Pediatrics) (SessionID 1220102)
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Content Type
Presentation
Knowledge Area
Pharmacology
Membership Level
Professional
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Tag
Pharmacology
Year
2023
Keywords
hydrocortisone
blood pressure
septic patients
brain death
organ recovery
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