SCCM Resource Library-Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial

Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial

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Video Transcription

Video Summary

The presenter discusses a trial on lung and diaphragm protective ventilation, which aims to prevent diaphragm weakness and improve outcomes for ICU patients. The diaphragm, the most important muscle for inspiration, can become weakened in ICU patients, leading to difficulty weaning from mechanical ventilation. The trial tested a new approach to mechanical ventilation that focuses on obtaining low lung stress and keeping diaphragm activity in the physiological range. The researchers conducted a randomized controlled trial in which they titrated inspiratory support to diaphragm effort in ICU patients on partially supported mechanical ventilation. The results showed that the intervention group had a higher percentage of breaths within the physiological range compared to the control group. The titration did not affect parameters of lung protective ventilation, such as tidal volume and driving pressures, and no significant differences were observed in biomarkers for lung injury. The study suggests that titration of support to diaphragm effort is feasible and effective, but larger trials are needed to assess its impact on patient outcomes.

Asset Subtitle

Pulmonary, Procedures, 2022

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2022 Critical Care Congress held from April 18-21, 2022.

Meta Tag

Content Type Presentation

Knowledge Area Pulmonary

Knowledge Area Procedures

Knowledge Level Advanced

Membership Level Select

Tag Ventilation

Year 2022

Keywords

lung and diaphragm protective ventilation

ICU patients

diaphragm weakness

mechanical ventilation

randomized controlled trial

diaphragm effort

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