SCCM Resource Library-Management of Bleeding due to Anticoagulants

Video Transcription

Video Summary

The presentation focuses on strategies for pharmacologic anticoagulation reversal. It highlights available anticoagulants and underscores the importance of understanding the coagulation cascade, pharmacokinetics, and pharmacodynamics for selecting appropriate reversal agents. For heparin and warfarin, agents like protamine and four-factor PCC are discussed, while specific reversal agents for newer anticoagulants, such as idaresuzumab and andexanet-alpha, are examined through studies like REVERSE-AD and INEXA-4. The presenter also explores guidelines from various medical societies, noting discrepancies in recommendations, especially concerning DOACs. The need for institutional guidelines is emphasized due to the limited and sometimes conflicting literature. Additionally, there's a spotlight on seroparentatag, a promising new agent capable of reversing multiple anticoagulants. Key takeaways include the importance of understanding anticoagulation pharmacology, evaluating limited reversal data, and considering future developments in novel agents.

Asset Caption

One-Hour Concurrent Session | All Bleeding Stops Eventually: A Review of Normal and Abnormal Coagulation

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

anticoagulation reversal

coagulation cascade

reversal agents

DOAC guidelines

seroparentatag

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