Managing Multiorgan Disease in Acute-On-Chronic Liver Failure: Improving Critical Care Management of the HRS/AKI Patient
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Video Transcription
Video Summary
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Pulmonary, GI and Nutrition, Renal, 2022
Asset Caption
This session is for critical care medicine professionals involved in managing multiorgan failure arising as a consequence of acute-on-chronic liver failure (ACLF), including hepatorenal syndrome/acute kidney injury (HRS/AKI), and the risks of acute respiratory distress syndrome (ARDS) in patients undergoing albumin revolumization.

Learning Objectives:
-Discuss the terms cirrhosis, decompensation, and acute-on-chronic liver failure (ACLF), as well as their clinical significance and risk to patient mortality
-Review current evidence for the whole-patient management of multiorgan failure arising from ACLF, including risks to renal and respiratory function
-Apply evidence-based fluid management protocols to revolumize patients with ascites following large-volume paracentesis in AKI patients to establish a diagnosis of HRS/AKI, while mitigating risks from fluid overload
-Intervene with proactive evidence-based vasoconstrictor therapy for patients who meet diagnostic criteria for HRS/AKI based on American Association for the Study of Liver Diseases (AASLD) and European Association for the Study of the Liver (EASL) algorithms
-Monitor patients with cirrhosis, ascites, and HRS/AKI for treatment-emergent adverse events that may worsen prognosis

This program is supported by an education grant from Mallinckrodt
Meta Tag
Content Type Presentation
Knowledge Area Pulmonary
Knowledge Area Renal
Knowledge Area GI and Nutrition
Knowledge Level Intermediate
Knowledge Level Advanced
Membership Level Select
Tag Acute Respiratory Distress Syndrome ARDS
Tag Liver
Tag Renal
Tag Updates and Future Directions
Year 2022
multi-organ disease
acute on chronic liver failure
hepatic encephalopathy
acute kidney injury
portal hypertension
early diagnosis
bedside echocardiography
hepatorenal syndrome
renal replacement therapy


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