SCCM Resource Library-Master Regulator: The Liver and Critical Illness

Video Transcription

Video Summary

The video discusses drug metabolism and dosing considerations in patients with liver failure, focusing on analgesics, sedatives, and antimicrobial therapies. Factors such as altered GI tract function and decreased perfusion to tissues can affect drug absorption, distribution, metabolism, and elimination in critically ill patients. The importance of an individualized approach to patient care is stressed, considering factors such as hepatic blood flow, protein binding, and intrinsic liver metabolism. Practical considerations for drug dosing in liver failure patients are provided, including the use of acetaminophen for pain control, avoidance of non-steroidal anti-inflammatory drugs, and the use of low doses and regular monitoring for sedatives. In another session, topics related to liver failure management are discussed. These include intracranial pressure management in acute liver failure, challenges of coagulation management, considerations for ICU patients with liver failure, use of renal replacement therapy for hyperammonemia, venous thromboembolism prophylaxis, impact of the microbiome on liver failure, targeted therapies, and the use of rifaximin in hepatic encephalopathy. The session highlights the need for individualized care, a multidisciplinary approach, and the modification of the microbiome in chronic liver conditions.

Asset Subtitle

GI and Nutrition, Pharmacology, 2020

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2020 Critical Care Congress held February 16-19, 2020, in Orlando, Florida, USA.

Learning Objectives

Describe the manifestations of neurologic dysfunction in acute and chronic liver failure
Assess the impact of liver dysfunction on the hematologic system
Assess the impact of liver dysfunction on the kidney
Elucidate new treatment strategies

Teaching an Old Dog New Tricks: The Liver-Brain Connection

Ram M. Subramanian

Bleeding or Thrombosis: A Hematologic Conundrum in ALF/ACLF

Constantine J. Karvellas

Medication Challenges: Dosing and Unusual Infections

William J. Peppard

Hepatorenal Patients: What to Do When Electrolytes Are out of Whack

Kai Singbartl

The Liver Is Failing: Should We Target the Microbiome?

Jody C. Olson

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Area GI and Nutrition

Knowledge Level Foundational

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Liver

Tag Anticoagulation

Tag Analgesia and Sedation

Year 2020

Keywords

drug metabolism

dosing considerations

liver failure

analgesics

sedatives

antimicrobial therapies

altered GI tract function

decreased perfusion

drug absorption

distribution

metabolism

elimination

individualized approach

hepatic blood flow

protein binding

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.