SCCM Resource Library-Metabolic Maps in Pediatric Sepsis

Video Transcription

Video Summary

The role of mitochondria in sepsis-induced multiple organ dysfunction syndrome (MODS) was discussed in this video. Mitochondria are responsible for producing energy in the form of ATP, and disruptions in this process can lead to a bioenergetic crisis and cell injury. Abnormalities in mitochondrial structure and function have been observed in various organ systems in both preclinical and human studies of sepsis. The study of mitochondrial function has been challenging, but research using peripheral blood mononuclear cells (PBMCs) has shown that septic patients have impaired oxygen consumption compared to healthy controls. Additionally, mitochondrial biogenesis and content have been found to be important in rescuing the mitochondrial phenotype in sepsis-induced MODS. The selective loss of butyrate-producing bacteria from the microbiome may also impact mitochondrial biogenesis and recovery from sepsis-induced MODS. Finally, in vitro studies have shown that butyrate may have therapeutic potential in restoring mitochondrial oxygen consumption. Overall, targeting mitochondrial dysfunction may offer a novel therapeutic approach to improve outcomes in sepsis patients.

Asset Subtitle

Sepsis, Pediatrics, 2023

Asset Caption

Type: one-hour concurrent | Metabolic Drivers of Sepsis: Roadside Diners (SessionID 1201356)

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Pediatrics

Membership Level Professional

Membership Level Select

Tag Scoring Systems

Tag Pediatrics

Year 2023

Keywords

mitochondria

sepsis-induced multiple organ dysfunction syndrome

ATP production

mitochondrial structure and function

oxygen consumption

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