SCCM Resource Library-Models of Translational Research in Critical Care

Video Transcription

Video Summary

The webcast titled "Models of Translational Research in Critical Care" discussed the importance of translational research and collaboration between different fields in the development of therapies for critical care patients. Dr. Sam Poliak, a professor of pharmaceutical sciences, discussed his own research on the role of drug metabolizing enzymes in critical care, specifically focusing on the conversion of arachidonic acid by cytochrome P450 enzymes. His research showed that inhibiting the formation of a metabolite called 20 HET could potentially reduce neuronal injury and improve outcomes in critical care patients. Dr. Poliak emphasized the need for understanding drug exposure and target engagement in humans and the importance of developing drugs with adequate concentrations and selectivity. He described how he formed a collaborative research team, bringing together expertise from various disciplines, including critical care medicine, nursing, and chemistry. The team conducted preclinical and clinical research to evaluate the effectiveness of their interventions. Dr. Poliak also discussed ongoing work to develop drug-like compounds that can effectively inhibit the target enzyme. This work involved screening hundreds of compounds for potency, selectivity, stability, and other characteristics. The ultimate goal is to develop therapies that can be administered intravenously and have long-lasting effects in reducing neuronal injury and improving outcomes for critical care patients.

Asset Subtitle

Research, Quality and Patient Safety, 2020

Asset Caption

Despite a growing prominence in the lexicon of critical care research, many critical care researchers and clinicians are unclear as to what defines translational research and how it differs from basic science and clinical research. The webinar will provide an overview of the spectrum of translational research, differentiate this field from basic and clinical research, and describe various models for building a successful multiprofessional translational research program.

Meta Tag

Content Type Webcast

Knowledge Area Research

Knowledge Area Quality and Patient Safety

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Research

Tag Evidence Based Medicine

Year 2020

Keywords

Models of Translational Research in Critical Care

translational research

collaboration

therapies for critical care patients

drug metabolizing enzymes

cytochrome P450 enzymes

20 HET metabolite

neuronal injury

target engagement

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