SCCM Resource Library-Mortality as a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients (CCM)

Mortality as a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients (CCM)

Video Transcription

Video Summary

In this video, the speaker discusses mortality in critical care trials and how it is measured. Mortality is commonly used as the principal endpoint in these trials, and the most commonly used time point is 28 or 30-day mortality. The speaker explains that mortality measures can vary in terms of short-term, medium-term, and longer-term time points, as well as location-based measures such as ICU discharge mortality and hospital discharge mortality. The speaker presents the findings of a systematic review of randomized control trials in critical care patients, which showed that the survival curves continue to diverge until at least day 60, indicating that mortality differences between intervention and control groups can be detected up to this point. The speaker suggests that longer follow-up periods, such as 60 to 90 days, should be considered in future trials to maximize survival curve separation and statistical power.

Asset Subtitle

Quality and Patient Safety, 2023

Asset Caption

Type: two-hour concurrent | Late-Breaking Studies Affecting Patient Outcomes (SessionID 9000007)

Meta Tag

Content Type Presentation

Knowledge Area Quality and Patient Safety

Membership Level Professional

Membership Level Select

Tag Mortality

Year 2023

Keywords

mortality

critical care trials

measurement

time points

systematic review

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