SCCM Resource Library-New Drug, Who's Toxic? New and Emerging Drug Toxicities

Video Transcription

Video Summary

The video features multiple speakers discussing complex topics related to critical care. The first speaker addresses toxicities from immune checkpoint inhibitors and targeted cancer therapies, including immune effector cell therapy, cytokine release syndrome (CRS), and immune effector cell-associated neurotoxicity syndrome (ICANS). CAR T-cell therapy, a revolutionary but toxic cancer treatment, is highlighted, with emphasis on conditions like CRS, ICANS, and their management in intensive care units (ICUs). <br /><br />Another segment focuses on euglycemic ketoacidosis, especially linked to SGLT2 inhibitors, a class of drugs used for diabetes which can lead to this condition. The importance of recognizing and managing euglycemic ketoacidosis in patients under certain treatments, including continuous renal replacement therapy, is stressed.<br /><br />The final speaker discusses recreational drug toxicities, emphasizing substances like synthetic cannabinoids, fentanyl, xylosine, ketamine, and psilocybin. The presentation notes an alarming rise in the use and complications from these drugs, advises on supportive care strategies, and highlights the role of naloxone in opioid overdoses. They conclude by underscoring the importance of recognizing the potential for polysubstance use in overdose cases to tailor treatment effectively.

Asset Caption

One-Hour Concurrent Session | New Drug, Who's Toxic? New and Emerging Drug Toxicities

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

critical care

immune checkpoint inhibitors

cytokine release syndrome

CAR T-cell therapy

euglycemic ketoacidosis

SGLT2 inhibitors

recreational drug toxicities

synthetic cannabinoids

naloxone

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