SCCM Resource Library-New Set of Eyes to Study Sepsis Mechanisms in Human Organs

Video Transcription

Video Summary

In this talk, John Riley, an assistant professor of medicine at the University of Pennsylvania, discusses the challenges in developing therapeutics for sepsis and how COVID-19 has changed the progress in studying sepsis mechanisms. He explains that while current therapies for sepsis have improved mortality rates, they remain largely supportive and focused on pathogen eradication. He highlights the long list of failed therapies in sepsis and how COVID-19 has brought success to drugs targeting the immunologic host response. Riley explores new ways to study sepsis in human organs, such as organs on a chip, ex vivo lung perfusion, and the use of patient biospecimens. He provides examples of how these models can help understand organ dysfunctions in sepsis and potentially test novel therapeutics. Finally, he highlights the breakthroughs in studying sepsis through genomics, transcriptomics, proteomics, and biomarkers to identify populations that would benefit from specific therapies.

Asset Subtitle

Sepsis, Immunology, 2022

Asset Caption

This session will examine and explain the progress made in the understanding of the immunology of sepsis following the COVID-19 pandemic. Speakers will bring fresh insights from large international cohorts and detailed molecular mechanistic studies.

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Immunology

Knowledge Level Advanced

Learning Pathway Sepsis Resources

Membership Level Select

Tag Sepsis

Tag Infectious Diseases

Year 2022

Keywords

sepsis therapeutics

COVID-19

pathogen eradication

organ dysfunction

genomics

Sepsis

Immunology

Sepsis

Infectious Diseases

Presentation

Select

2022

Advanced

Sepsis Resources

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