SCCM Resource Library-Not Your Grandparents' Evidence: Advancing Critical Care Research and Practice Through Real-World Evidence

Not Your Grandparents' Evidence: Advancing Critical Care Research and Practice Through Real-World Evidence

Video Transcription

Video Summary

The speaker, with disclosures of funding and advisory roles, aims to elucidate real-world data (RWD) and real-world evidence (RWE) in clinical settings. RWE is defined by the FDA as clinical evidence drawn from RWD, which comprises data from everyday medical interactions, insurance claims, and even wearable devices. This data is increasingly linked and used for various medical trials, notably pragmatic clinical trials that offer broader, more inclusive studies than traditional ones. Examples are given, including environmental data usage and innovative trial designs such as target trial emulation, which mimics randomized control trial (RCT) conditions. Advances in machine learning and data quality are enhancing RWE, making it pivotal in post-marketing surveillance and rare condition studies. However, it cannot replace RCTs entirely due to potential data gaps and integration challenges, highlighting the need for high-quality data and careful study design.

Asset Caption

Two-Hour Concurrent Session | Curating and Analyzing Real-World Data for Critical Care Research in COVID-19 and Beyond

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

real-world evidence

pragmatic clinical trials

machine learning

data quality

target trial emulation

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