SCCM Resource Library-Novel Clinical Trial Designs

Video Transcription

Video Summary

Dr. David Wong, professor of critical care and emergency medicine at the University of Pittsburgh, discussed novel clinical trial designs in a webcast titled "Novel Clinical Trial Designs." He introduced the concept of randomized embedded multi-factorial adaptive platform (REMAP), which allows for learning while doing in clinical trials. Traditionally, there has been a separation between clinical research and clinical practice, with researchers focused on generating future knowledge and practitioners focused on treating patients. However, this approach is inefficient and not ideal, especially during a pandemic. The REMAP approach aims to bridge this gap by designing trials that are friendlier to bedside care and provide a higher probability of patients receiving novel treatments that work. Dr. Wong also discussed the REMAP-CAP COVID trial, a global adaptive platform trial for severe pneumonia in the ICU that was activated as a pandemic appendix. He highlighted the challenges and implementation strategies faced in launching the trial, including leadership engagement, trial embedment into routine care processes, electronic medical record integration, and regulatory compliance. Dr. Wong also introduced Optimize C19, a trial focused on evaluating the comparative effectiveness of monoclonal antibodies for COVID-19. He discussed the design and operation of the trial, as well as the challenges and future directions. Overall, Dr. Wong's presentation emphasized the importance of novel clinical trial designs in improving patient care and outcomes.

Asset Subtitle

Research, 2021

Asset Caption

Randomized clinical trials are the gold standard for establishing cause and effect. Traditional approaches have been limited by feasibility and generalizability concerns. In recent years, numerous novel methods have been developed to address these issues. This webcast from Discovery, the Critical Care Research Network, and the Clinical Pharmacy and Pharmacology Section will review key advances, including adaptive randomization, pragmatic designs, platform trials, trials based on electronic health records, and more.

Meta Tag

Content Type Webcast

Knowledge Area Research

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Associate

Membership Level Professional

Tag Clinical Research Design

Year 2021

Keywords

Dr. David Wong

critical care

emergency medicine

University of Pittsburgh

novel clinical trial designs

REMAP

randomized embedded multi-factorial adaptive platform

clinical research

clinical practice

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