SCCM Resource Library-November Journal Club: Spotlight on Pharmacy (2020)

Video Transcription

Video Summary

In this video transcript, three presenters discuss the results of three different studies related to critical care medicine. The first presenter discusses a randomized controlled trial that evaluated the effects of melatonin supplementation on sleep quality in ICU patients. The study found that melatonin was associated with better sleep quality, particularly in the area of sleep depth. However, the study had some limitations, including small sample size and subjective sleep assessments by nurses. The presenter concludes that while the benefit of melatonin may outweigh the harm, the study does not provide strong evidence for routine use of melatonin in critically ill patients.<br /><br />The second presenter discusses a study that compared therapeutic and prophylactic anticoagulation in COVID-19 patients with acute respiratory distress syndrome (ARDS). The study found that therapeutic anticoagulation with low molecular weight heparin improved oxygenation and increased the rate of successful extubation compared to prophylactic anticoagulation. However, the study was small and not powered to detect significant differences in mortality or bleeding rates, so further research is needed to guide anticoagulation management in COVID-19 patients.<br /><br />The third presenter discusses a study that evaluated the effects of therapeutic anticoagulation with enoxaparin on oxygenation in mechanically ventilated COVID-19 patients. The study found that therapeutic anticoagulation improved oxygenation over time and increased the rate of successful extubation. However, the study was small and not powered to detect significant differences in mortality or bleeding rates, so further research is needed to determine the optimal anticoagulation strategy in critically ill COVID-19 patients.<br /><br />Overall, these studies provide some insights into the use of melatonin and anticoagulation in critically ill and COVID-19 patients, but more research is needed to guide clinical practice.

Asset Subtitle

Pharmacology, Research, 2020

Asset Caption

"The Journal Club: Spotlight on Pharmacy webcast series focuses on pharmacy topics. This event is held on the third Friday of each month and features lively discussion and in-depth presentations on the latest research.

Follow the conversation at #SCCMCPPJC."

Meta Tag

Content Type Webcast

Knowledge Area Pharmacology

Knowledge Area Research

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Pharmacology

Tag Research

Year 2020

Keywords

critical care medicine

melatonin supplementation

sleep quality

ICU patients

randomized controlled trial

therapeutic anticoagulation

prophylactic anticoagulation

COVID-19 patients

acute respiratory distress syndrome

mechanically ventilated patients

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.