This article was first published in the Winter 2022 issue of Critical Connections. Errors associated with administration of IV medications are a primary safety concern for hospitals. Many medication errors can be prevented via safe medication practices, including the use of smart infusion pumps. Nearly 20 years after the introduction of smart infusion pumps with dose error reduction software, there are opportunities for the continued improvement of medication safety in critical care. Because of the significant volume of IV medications administered in hospitals, infusion pumps are widely used, with an estimated 90% of hospital patients receiving infusions using this technology. Authors: Nicole T. Reardon, PharmD, BCPS, FCCM Hildy M. Schell-Chaple, PhD, RN, CCNS, FAAN Sonia Mathews, PharmD, BCPS Megan A. Rech, PharmD, MS, BCCCP, FCCM Critical Connections, the critical care industry's only newsmagazine, provides information on cutting-edge topics in critical care useful to the entire multiprofessional team. Authors: Nicole T. Reardon, PharmD, BCPS, FCCM Hildy M. Schell-Chaple, PhD, RN, CCNS, FAAN Sonia Mathews, PharmD, BCPS Megan A. Rech, PharmD, MS, BCCCP, FCCM