SCCM Resource Library-Pediatric Antimicrobial Dosing: Is There More to Consider Than Age and Weight?

Video Transcription

Video Summary

In this video, Dr. Hector Wong discusses the concept of precision antimicrobial dosing in pediatric patients with sepsis. He explains that precision dosing involves optimizing antimicrobial dosages to achieve the desired drug levels using pharmacokinetic and pharmacodynamic modeling. Dr. Wong describes how biomarkers can be used to predict mortality risk in pediatric septic shock patients, and how these biomarkers can also be used to predict mortality in mice models of sepsis. He discusses the potential of using biomarkers to select patients who could benefit from precision dosing. Dr. Wong presents data showing that mice at high baseline risk of mortality have a greater bacterial burden and can be rescued with higher-dose antibiotics. He also presents data suggesting that children at high risk of mortality as determined by biomarkers have a greater bacterial burden. Dr. Wong suggests that biomarkers could serve as an enrichment strategy for selecting patients for precision antibiotic dosing. He concludes by stating that more research is needed in this area, but precision dosing could be a promising approach to improve patient outcomes in pediatric sepsis.

Asset Subtitle

Pediatrics, Sepsis, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Illustrate methods for improving outcomes of pediatric patients with severe infections using pharmacokinetics to optimize antimicrobial dosing
Describe and appraise animal model data supporting the use of personalized pharmacometrics that optimize antimicrobial dosing to improve survival
Demonstrate how different antimicrobial adsorption and clearance profiles impact optimization of dosing while on extracorporeal therapies such as continuous renal replacement therapy or extracorporeal membrane oxygenation

Improving Patient Outcomes Through Optimizing Antimicrobial Dosing
Gideon Stitt

Proof of Principle: Animal Models for Precision Antimicrobial Dosing
Hector R. Wong

Meta Tag

Content Type Presentation

Knowledge Area Pediatrics

Knowledge Area Sepsis

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Antibiotics

Tag Pharmacokinetics Pharmacodynamics

Year 2021

Keywords

precision antimicrobial dosing

pediatric patients

sepsis

biomarkers

mortality risk

mice models

bacterial burden

patient outcomes

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