SCCM Resource Library-Pediatrics Year in Review 2021 Basic Science

Video Transcription

Video Summary

In this Pediatrics Year in Review, the speaker focuses on advancements in the field of trained immunity, which refers to the adaptive nature of the innate immune system based on prior exposures and stimuli. They discuss four key papers from 2021. The first paper highlighted the impact of prenatal exposures on tissue susceptibility to infection and auto-inflammatory disorders. In the second paper, sequential viral infections were explored in relation to immune response and outcomes, with a focus on the importance of an intact interferon response. The third paper investigated the epigenomic and transcriptional consequences of influenza vaccination, showing that vaccination can modify the inflammatory response to unrelated stimuli. The final paper compared the local and systemic responses to SARS-CoV-2 in children and adults, revealing age-related differences and an increase in baseline antiviral interference signaling in children. These findings raise important questions about harnessing trained immunity to improve disease tolerance and outcomes in pediatric patients.

Asset Subtitle

Professional Development and Education, Quality and Patient Safety, 2022

Asset Caption

This session will present standout papers from the past year in the areas of basic research, clinical research, and education, quality, and safety.

Meta Tag

Content Type Presentation

Knowledge Area Professional Development and Education

Knowledge Area Quality and Patient Safety

Knowledge Level Foundational

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Professional Development

Tag Evidence Based Medicine

Year 2022

Keywords

trained immunity

pediatrics

innate immune system

viral infections

influenza vaccination

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.