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Pediatrics Year in Review 2021 Basic Science
Pediatrics Year in Review 2021 Basic Science
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Video Summary
In this Pediatrics Year in Review, the speaker focuses on advancements in the field of trained immunity, which refers to the adaptive nature of the innate immune system based on prior exposures and stimuli. They discuss four key papers from 2021. The first paper highlighted the impact of prenatal exposures on tissue susceptibility to infection and auto-inflammatory disorders. In the second paper, sequential viral infections were explored in relation to immune response and outcomes, with a focus on the importance of an intact interferon response. The third paper investigated the epigenomic and transcriptional consequences of influenza vaccination, showing that vaccination can modify the inflammatory response to unrelated stimuli. The final paper compared the local and systemic responses to SARS-CoV-2 in children and adults, revealing age-related differences and an increase in baseline antiviral interference signaling in children. These findings raise important questions about harnessing trained immunity to improve disease tolerance and outcomes in pediatric patients.
Asset Subtitle
Professional Development and Education, Quality and Patient Safety, 2022
Asset Caption
This session will present standout papers from the past year in the areas of basic research, clinical research, and education, quality, and safety.
Meta Tag
Content Type
Presentation
Knowledge Area
Professional Development and Education
Knowledge Area
Quality and Patient Safety
Knowledge Level
Foundational
Knowledge Level
Intermediate
Knowledge Level
Advanced
Membership Level
Select
Tag
Professional Development
Tag
Evidence Based Medicine
Year
2022
Keywords
trained immunity
pediatrics
innate immune system
viral infections
influenza vaccination
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