SCCM Resource Library-Personalized Medicine Versus Protocolized Care for Sepsis

Video Transcription

Video Summary

In this presentation, Dr. Ricard Ferrer discusses the variability in the treatment of sepsis and the use of protocols. He highlights the IMPRESS study, which showed variability in bundle compliance and mortality rates between different areas of the world. He also mentions the variability in time to antibiotics and emphasizes the importance of using protocols in order to reduce variability and improve patient outcomes. However, he also notes that protocols alone are not a guarantee of better care and that protocols should be used to guide clinical knowledge and expertise. <br /><br />Dr. Samantha Gambles-Farr introduces the concept of personalized medicine, or precision medicine, which involves tailoring medical treatment based on the individual characteristics of each patient. She discusses the use of biomarkers and genetic analysis to identify patient subgroups and how this can inform treatment decisions. She also mentions the importance of considering the diversity of infecting pathogens in sepsis and the use of rapid molecular assays to quickly identify and target specific pathogens.<br /><br />Dr. Philip Dellinger discusses the benefits of using protocols for the management of sepsis, particularly for less experienced clinicians. He emphasizes that protocols allow for scientific rigor and can be evaluated for their effectiveness. He also discusses the concept of precision medicine, using biomarkers, genomics, and machine learning to personalize treatment based on individual patient characteristics. He mentions the importance of tailoring treatment for specific subgroups, such as those with comorbidities like heart failure or end-stage renal disease. He also highlights the potential of phenotyping and machine learning to further advance precision medicine in sepsis. In summary, the speakers agree that both protocolized and personalized approaches to sepsis management are necessary. Protocols provide a standardized framework for care, while precision medicine allows for individualized treatment based on patient characteristics and underlying biology.

Asset Subtitle

Sepsis, Research, 2020

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2020 Critical Care Congress held February 16-19, 2020, in Orlando, Florida, USA.

Learning Objectives

Review the benefits of standardized approaches and protocolized care for patients with sepsis
Discuss the value of a personalized approach to sepsis treatment and prediction established on the basis of novel approaches to biological classification
Describe an integrated approach that combines elements of personalized and protocolized medicine

The Case for Protocolized Sepsis Management

Ricard Ferrer

Precision Medicine for Sepsis

Hector R. Wong

Protocolized and Precision Approaches Are Both Needed

R. Phillip Dellinger

Meta Tag

Content Type Presentation

Knowledge Area Sepsis

Knowledge Area Research

Knowledge Level Foundational

Learning Pathway Sepsis Resources

Membership Level Select

Membership Level Professional

Membership Level Associate

Tag Guidelines

Tag Infection

Year 2020

Keywords

sepsis treatment

protocol variability

IMPRESS study

bundle compliance

mortality rates

personalized medicine

biomarkers

genetic analysis

precision medicine in sepsis

machine learning

Sepsis

Research

Guidelines

Infection

Presentation

Select

Professional

Associate

2020

Foundational

Sepsis Resources

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