SCCM Resource Library-Perspective: Desensitization Beyond Antibiotics

Video Transcription

Video Summary

In this video, Dr. Ibrahim Alsanouri discusses drug allergy in the intensive care unit (ICU). He discusses the importance of understanding the terminology and classification of drug allergy reactions. Dr. Alsanouri explains that drug hypersensitivity reactions are immune-mediated responses to a medication that may involve different types of immune responses, including IgE pathways and cytokines. He emphasizes the need to differentiate drug hypersensitivity reactions from side effects or toxicity and classifies reactions based on timing, immune pathophysiology, and mechanism of action. Dr. Alsanouri also highlights the risk factors for drug hypersensitivity reactions, such as drug dose, form of administration, drug molecule size, and the presence of certain diseases or individual-specific MHC or HLA molecules. He discusses the epidemiology of drug hypersensitivity reactions and their impact on healthcare costs and patient outcomes. In addition, Dr. Alsanouri explains that specific drugs can cause specific clinical features, and being aware of these associations can help identify the culprit medication. He concludes by emphasizing the importance of precise classification of drug hypersensitivity reactions to enable effective management and minimize morbidity and mortality.

Asset Subtitle

Pharmacology, 2021

Asset Caption

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the 2021 Critical Care Congress held virtually from January 31-February 12, 2021.

Learning Objectives

Explain the utility of desensitization protocols to overcome medication hypersensitivity in the intensive care unit
Discuss logistical and operational opportunities and challenges involved with implementing desensitization protocols in the intensive care unit

Demystifying Desensitization: Practical Considerations for Drug Desensitization Procedures in the ICU
Ibrahim Al-Sanouri

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Level Intermediate

Knowledge Level Advanced

Membership Level Select

Tag Antibiotics

Tag Drug Interactions

Year 2021

Keywords

drug allergy

intensive care unit

drug hypersensitivity reactions

immune-mediated responses

classification

risk factors

management

	Society of Critical Care Medicine 500 Midway Drive Mount Prospect, IL 60056 USA Phone: +1 847 827-6888 Fax: +1 847 439-7226 Email: support@sccm.org	Contact Us About SCCM Newsroom Advertising & Sponsorship DONATE	MySCCM LearnICU Patients & Families Surviving Sepsis Campaign Critical Care Societies Collaborative	GET OUR NEWSLETTER
© Society of Critical Care Medicine. All rights reserved. \| Privacy Statement \| Terms & Conditions The Society of Critical Care Medicine, SCCM, and Critical Care Congress are registered trademarks of the Society of Critical Care Medicine.