SCCM Resource Library-Pharmacologic Treatment of Refractory ICU Delirium

Video Transcription

Video Summary

The speaker discusses the pharmacologic treatment of refractory ICU delirium. They review the PADIS guidelines for pharmacotherapy for delirium, which include not using haloperidol or atypical antipsychotics. They also discuss the MIND and MIND USA studies, which found no difference in outcomes between different treatment groups. Dexmedetomidine is recommended for delirium in mechanically ventilated adults. The speaker also mentions other agents to consider, such as valproic acid, clonidine, and guanfacine, but notes that more research is needed. Non-pharmacological therapy should be the first line of treatment for delirium.

Asset Subtitle

Neuroscience, Pharmacology, 2022

Asset Caption

Delirium is common in many critically ill patients and is associated with increased duration of mechanical ventilation, duration of ICU and hospital lengths of stay, and long-term cognitive impairment. Patients may be refractory to multiple standard treatment modalities requiring alterative pharmacologic and nonpharmacologic treatment regimens. There are many research gaps in this area, and this session will help provide insight into multifaceted management strategies for refractory ICU delirium.

Meta Tag

Content Type Presentation

Knowledge Area Neuroscience

Knowledge Area Pharmacology

Knowledge Level Intermediate

Knowledge Level Advanced

Learning Pathway Delirium and Sedation Managment

Membership Level Select

Tag Delirium

Tag Pharmacology

Year 2022

Keywords

pharmacologic treatment

refractory ICU delirium

PADIS guidelines

dexmedetomidine

non-pharmacological therapy

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