SCCM Resource Library-Propofol Versus Dexmedetomidine: When and Why?

Video Transcription

Video Summary

In this video, Kirsten Cota, a clinical pharmacist at the Mayo Clinic, provides an overview of the use of propofol and dexmedetomidine in the trauma population. Trauma patients in the ICU have unique characteristics and needs, such as younger age, specialized management of injuries, and higher rates of intoxication. The choice between propofol and dexmedetomidine should consider the benefits and risks of each agent. Propofol is a lipophilic compound that has a rapid onset and is used for both light and deep sedation. It can decrease ICU length of stay and days of mechanical ventilation but has risks such as hypotension and metabolic abnormalities. Dexmedetomidine, on the other hand, is an alpha-2 agonist with analgesic properties. It facilitates non-invasive ventilation and has a minimal depressive effect. However, it can cause hypertension and bradycardia. Studies comparing the two agents in trauma patients have shown mixed results, with no significant differences in outcomes. The choice of sedation should be individualized based on the patient's specific needs and clinical status.

Asset Subtitle

Pharmacology, 2022

Asset Caption

This session will review common critical care management of trauma patients as it relates to sedation, pain management, and delirium. The use of opioids for pain management includes the potential risks of addiction, abuse, and misuse of opioids as patients transition out of the controlled ICU environment.

Meta Tag

Content Type Presentation

Knowledge Area Pharmacology

Knowledge Level Intermediate

Knowledge Level Advanced

Learning Pathway Delirium and Sedation Managment

Membership Level Select

Tag Analgesia and Sedation

Year 2022

Keywords

propofol

dexmedetomidine

trauma population

ICU

sedation

clinical status

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