SCCM Resource Library-Protocolized Care in Sepsis: EGDT and ProCESS, ProMISe, and ARISE

Protocolized Care in Sepsis: EGDT and ProCESS, ProMISe, and ARISE

Video Transcription

Video Summary

The speaker discusses the challenges clinicians face when interpreting varying results from multiple clinical trials, particularly in the context of sepsis treatment and resuscitation protocols. They focus on comparing the outcomes of the 2001 Early Goal-Directed Therapy (EGDT) study with subsequent multicenter trials: PROCESS, ARISE, and PROMISE. While the original EGDT study reported significant mortality reductions in septic shock, later studies did not replicate these findings, which may be due to improved sepsis management practices over time. The speaker highlights key differences between the trials, such as patient pre-treatment and timing of interventions, suggesting that changes in routine care like early recognition, fluid resuscitation, and antibiotic administration contribute significantly to patient outcomes. They caution against dismissing the value of sepsis protocols altogether, emphasizing the importance of early detection and consistent initial management as critical factors in improving survival rates.

Asset Caption

One-Hour Concurrent Session | When New Data Conflict With Old Data: Making Sense Through the Lens of Landmark Trials

Meta Tag

Content Type Presentation

Membership Level Professional

Membership Level Select

Year 2024

Keywords

sepsis treatment

clinical trials

EGDT study

resuscitation protocols

patient outcomes

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